Protein Domain : Thoeris protein ThsB, TIR-like domain superfamily IPR036490

Type	Homologous_superfamily
Description	This is the TIR-like domain of ThsB proteins, which adopts a Rossmann-like fold [ ]. ThsB is responsible for recognizing phage infection [].Thoeris is a bacterial antiphage defense system, which consists of two genes, thsA and thsB, via NAD+ degradation [ , , ]. ThsA has robust NAD+ cleavage activity and and a two-domain architecture containing a N-terminal NAD-binding domain (denoted as sirtuin-like or Macro) and C-terminal SLOG-like domain. In some instances, such as in B. amyloliquefaciens, ThsA has an N-terminal transmembrane domain []. ThsB (also referred to as TIR1 and TIR2) is structurally similar to TIR domain proteins but without enzymatic activity.
Short Name	ThsB_TIR-like_sf