Protein Domain : Protein kinase-like domain, Apicomplexa IPR027916

Type	Domain
Description	This entry represents the kinase-like domain found in the Rhoptry (ROP) pseudokinases from the intracellular parasite Toxoplasma gondii [ ]. ROP2, ROP4 and ROP8 have a typical bi-lobed protein kinase fold, but lack catalytic activity [].ROP4 is localised to the rhoptries, secretory organelles at the apical end of the parasite, and is secreted from the parasite during host cell invasion [ ]. ROP2 mediates an association between the parasitophorous vacuole (PV) and host cell mitochondria by inserting into the parasitophorous vacuole membrane (PVM) []. It plays important roles in rhoptry biogenesis, parasite invasion, and intracellular replication []. During host invasion, ROP2 is released from the vacuole membrane and becomes phosphorylated in the infected cells [].
Short Name	Kinase-like_dom_Apicomplexa