Protein Domain : Rho-associated protein kinase 2, catalytic domain IPR029878

Type	Domain
Description	Rho-associated protein kinases (ROCKs) were originally identified as small GTPase Rho effectors. Later, ROCKs were found actively phosphorylating many actin-binding proteins and intermediate filament proteins to modulate their functions [ ]. Two ROCK isoforms have been identified:ROCK1 (ROKb, p160ROCK) and ROCK2. As major downstream effectors of the small GTPase RhoA, they regulate cellular contraction, motility, morphology, polarity, cell division, and gene expression [ , ].This entry represents the catalytic domain of ROCK2. ROCK2 has a predominant role in vascular smooth muscle cell contractility [ ].
Short Name	ROCK2_cat