Protein Domain : Serine/Threonine kinase LKB1, catalytic domain IPR039154

Type	Domain
Description	Serine/threonine kinases (STKs) catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LKB1, also called STK11, was first identified as a tumour suppressor responsible for Peutz-Jeghers syndrome, a disorder that leads to an increased risk of spontaneous epithelial cancer. It serves as a master upstream kinase that activates AMP-activated protein kinase (AMPK) and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth [ ]. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development and function [, , , ]. Loss of LKB1 function in the liver results in hyperglycemia with increased gluconeogenic and lipogenic gene expression, indicating role as a mediator of glucose homeostasis []. To be activated, LKB1 requires the adaptor proteins STe20-Related ADaptor (STRAD) and mouse protein 25 (MO25)[].
Short Name	LKB1_c