Protein Domain : FKBP12-rapamycin binding domain superfamily IPR036738

Type  Homologous_superfamily
Description  The macrolide antibiotic rapamycin and the cytosol protein FKBP12 can form a complex which specifically inhibits the TORC1 complex, leading to growth arrest. The FKBP12-rapamycin complex interferes with TORC1 function by binding to the FKBP12-rapamycin binding domain (FRB) of the Tor proteins. This superfamily represents the FRB domain [ , ]. Proteins containing this domain include Tor proteins which are serine/threonine kinases conserved from fungi to humans. While higher eukaryotes such as humans possess a single Tor protein, yeasts contain two (Tor1 and Tor2) [].
Short Name  FRB_sf

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0 Gene Families

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1 Ontology Annotations

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