Protein Domain : Orthopoxvirus, Protein K7 IPR009174

Type  Family
Description  This family represents Protein K7 from Orthopoxvirus. K7 is Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation [ ]. It contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation and affects the acute immune response to infection [, , ]. In vaccinia virus, this protein has been related to the increase in cellular histone methylation during infection [].
Short Name  Orthopox_K7

0 Child Features

0 Gene Families

0 Genes

1 Ontology Annotations

1 Parent Features

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