v5.1.0.3
Cicer data from the Legume Information System
| Type | Family |
| Description | This family represents Protein K7 from Orthopoxvirus. K7 is Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation [ ]. It contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation and affects the acute immune response to infection [, , ]. In vaccinia virus, this protein has been related to the increase in cellular histone methylation during infection []. |
| Short Name | Orthopox_K7 |