Protein Domain : Fe(II) trafficking protein YggX superfamily IPR036766

Type	Homologous_superfamily
Description	The protein superfamily represented by this entry, YggX, serves to protect Fe-S clusters from oxidative damage [ ]. The effect is two-fold: proteins that rely on Fe-S clusters do not become inactivated, and the release of free iron and hydrogen peroxide--a DNA damaging agent--is prevented. These observations are consistent with the hypothesis that YggX chelates free iron, and recent experiments show that YggX can indeed bind Fe(II) in vitro and in vivo []. Furthermore, YggX has a positive effect on the action of at least one Fe(II)-responsive protein. The combined actions of YggX is reminiscent of iron trafficking proteins [], and YggX is therefore proposed to play a role in Fe(II) trafficking []. In Escherichia coli, YggX was shown to be under the transcriptional control of the redox-sensing SoxRS system [].Structurally, YggX has a beta(2)-alpha(3) fold and contains a zinc-less 'zinc finger'-like fold.
Short Name	Fe_traffick_prot_YggX_sf