Protein Domain : Vinculin, conserved site IPR000633

Type	Conserved_site
Description	Vinculin is a eukaryotic protein that appears to be involved in the attachment of actin-based microfilaments to the plasma membrane []. It also interacts with other structural proteins, such as talin [] and alpha-actinin. The protein is located on the cytoplasmic side of focal contacts or adhesion plaques. Vinculinis a large protein (~1000 residues) that contains an acidic N-terminal domain, separated from a smaller, basic C-terminal domain by a 50-residue proline-rich region []. The central part of the N-terminal domainconsists of a variable number of repeats of a 110-residue domain, one of which is lacking in nematode vinculin [].
Short Name	Vinculin_CS