Protein Domain : MRH domain IPR044865

Type	Domain
Description	The mannose 6-phosphate (Man-6-P) receptor homology (MRH) domain is present in recycling receptors (mannose 6-phosphate receptors, MRPs), resident endoplasmic reticulum (ER) proteins (glucosidase 2 beta subunit, Endoplasmic reticulum lectin 1 XTP3-B, OS-9), and in Golgi glycosyltransferase (GlcNAc-phosphotransferase gamma-subunit), which are characterised by the presence of one or more MRH domains. Many MRH domains act as lectins and bind specific phosphorylated (MPRs) or non phosphorylated (glycosidase 2 beta subunit, XTP3-B and OS-9) high mannose-type N-glycans. The MPRs are the only proteins known to bind Man-6-P residues via their MRH domains. The MRH domain can function in protein-carbohydrate and protein-protein interactions [ , , , , , ].This domain has a β-barrel structure formed by nine β-strands organised into two orthogonally oriented antiparallel β-sheet [, ].
Short Name	MRH_dom