Protein Domain : MoaD, archaeal-type IPR010038

Type	Family
Description	Members of this family appear to be mainly archaeal and bacterial versions of MoaD, subunit 1 of molybdopterin converting factor. Small archaeal modifier protein 1 (SAM1) is a member of this family and it is involved in protein tagging in an ubiquitin-like system from archaea known as SAMPylation [ ]. It is not known whether it is implicated in the targeting of proteins to the proteasome for degradation []. SAM1 is also essential for MoCo-dependent dimethyl sulphoxide reductase activity, suggesting that it functions in the sulphur-containing molybdenum cofactor (MoCo) biosynthesis [].SAM proteins, as Ub/Ubl proteins, have a β-grasp fold common to a growing superfamily of proteins involved in diverse functions. Among these functions, sulphur activation for the biosynthesis of thiamine, tungsten and molybdenum cofactors bears striking resemblance to the activation of Ub/Ubl [ ].
Short Name	MoaD_arc-typ