Protein Domain : SH2B1, SH2 domain IPR035057

Type  Domain
Description  This entry represents the SH2 domain of SH2B adapter protein 1.SH2B adapter protein 1 (SH2B1) belongs to the SH2B family of adapter proteins [ ]. It promotes insulin expression and glucose metabolism in beta-cells in mice []. It is also involved in brain-derived neurotrophic factor-induced neurite outgrowth [].SH2B family contains three members of adaptor proteins: SH2B1, 2 and 3 [ ]. Typical SH2B proteins contain a SH2 (Src homology 2) and a PH (pleckstrin homology) domain. They serve as adaptors involved in signalling by the receptors for growth factors, such as insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor [].
Short Name  SH2B1_SH2

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