LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Family |
| Description | This entry represents the haemagglutinin-esterase fusion glycoprotein (HEF) found specifically in infectious anaemia virus (ISAV), an orthomyxovirus-type virus that is an important fish pathogen in marine aquaculture [ , ]. Other viruses, such as influenza C virus, coronaviruses and toroviruses, also contain surface HEF proteins, but whereas they usually bind 9-O-acetylsialic acid receptors, ISAV HEF appears to bind 4-O- acetylsialic acid receptors []. Haemagglutinin-esterase fusion glycoprotein is a multi-functional protein embedded in the viral envelope of ISAV. HEF is required for infectivity, and functions to recognise the host cell surface receptor, to fuse the viral and host cell membranes, and to destroy the receptor upon host cell infection. The haemagglutinin region of HEF is responsible for receptor recognition and membrane fusion. The serine esterase region of HEF is responsible for the destruction of the receptor, though it appears to be distinct from the esterase domain found in influenza C virus.Haemagglutinin-esterase glycoproteins must usually be cleaved by the host's trypsin-like proteases to produce two peptides (HEF1 and HEF2) necessary for the virus to be infectious. The cleaved HEF protein can then fuse the viral envelope to the cellular membrane of the host cell, which allows the virus to infect the host cell. |
| Short Name | Hemagglutn-estrase_ISAV-type |
