Protein Domain : Lipid transport, open beta-sheet IPR009454

Type	Domain
Description	This entry represents a conserved open β-sheet domain found in several lipid transport proteins, including vitellogenin and apolipoprotein B-100 [ ].Vitellinogen precursors provide the major egg yolk proteins that are a source of nutrients during early development of oviparous vertebrates and invertebrates. Vitellinogen precursors are multi-domain apolipoproteins that are cleaved into distinct yolk proteins. Different vitellinogen precursors exist, which are composed of variable combinations of yolk protein components; however, the cleavage sites are conserved. In vertebrates, a complete vitellinogen is composed of an N-terminal signal peptide for export, followed by four regions that can be cleaved into yolk proteins: heavy chain lipovitellin (lipovitellin-1), phosvitin, light chain lipovitellin (lipovitellin-2), and a von Willebrand factor type D domain (YGP40) [ , ]. In vitellinogen, this domain is often found as part of the lipovitellin-1 peptide product. Apolipoprotein B can exist in two forms: B-100 and B-48. Apoliporotein B-100 is present on several lipoproteins, including very low-density lipoproteins (VLDL), intermediate density lipoproteins (IDL) and low density lipoproteins (LDL), and can assemble VLDL particles in the liver [ ]. Apolipoprotein B-100 has been linked to the development of atherosclerosis.
Short Name	Lipid_transpt_open_b-sht