Protein Domain : Non-structural protein 14, coronavirus IPR009466

Type  Domain
Description  The unique coronavirus (CoV) transcription/replication machinery comprised of multiple virus-encoded non structural proteins (NSP) plays a vital role during initial and intermediate phases of the viral life cycle. This entry represents NSP14, encoded as part of polyprotein pp1ab and excised by NSP5. Its N-terminal exoribonuclease (ExoN) domain plays a proofreading role for prevention of lethal mutagenesis, and the C-terminal domain functions as an S-adenosyl methionine (SAM)-dependent (guanine-N7) methyl transferase (N7-MTase) for mRNA capping [, , , , , ]. NSP14 forms the nsp14-nsp10 complex involved in RNA viral proofreading [, ].
Short Name  NSP14_CoV

4 Child Features

0 Gene Families

0 Genes

2 Ontology Annotations

0 Parent Features

0 Publications

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