Protein Domain : Methanol oxidation system protein MoxJ IPR022455

Type	Family
Description	This entry represents a predicted periplasmic protein, called MoxJ or MxaJ and is required for methanol oxidation in Methylobacterium extorquens [ ].There are two differing opionions suggesting the role of this protein. The first is based on the homology of MoxJ, and suggests that it is the substrate-binding protein of an ABC transporter associated with methanol oxidation. The gene is also found in genomes with and only two or three genes away from a corresponding permease and ATP-binding cassette gene pair.The other opinion, is that MoxJ is an accessory factor or additional subunit of methanol dehydrogenase itself [ ]. Mutational studies show a dependence of MoxJ for the expression of the PQQ-dependent two-subunit methanol dehydrogenase (MxaF and MxaI) in Methylobacterium extorquens, possibly acting as a chaperone for enzyme assembly or a third subunit. A homologous N-terminal sequence was found in Acetobacter methanolicus as a 32Kd third subunit [].It is thought that MoxJ may in fact be both, a component of a periplasmic enzyme that converts methanol to formaldehyde and a component of an ABC transporter that delivers the resulting formaldehyde to the cells interior.
Short Name	Methanol_oxidation_MoxJ