Protein Domain : Transmembrane protein 127, transmembrane region IPR046795

Type  Domain
Description  Transmembrane protein 127 (TMEM127) modulates mTOR function in the endolysosome. Its interaction with early endosomal GTPase Rab5 to inhibit mTOR signalling seems to be related with its tumour-suppressing properties [ , ]. This entry represents the transmembrane region of this protein and similar animal sequences.
Short Name  TMEM127_TM
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