Protein Domain : MICOS complex subunit MIC26/MIC27, animal IPR033182

Type	Family
Description	This entry represents MICOS complex subunit MIC26, and its paralogue, MIC27, from animals. The MICOS complex is a central player determining mitochondrial cristae structure and formation of crista junctions [ ]. Human MIC26 (also known as apolipoprotein O, APOO) plays a crucial role in crista junction formation and mitochondrial function [ ] and can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts []. It promotes cholesterol efflux from macrophage cells and can be detected in HDL, LDL and VLDL. It is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL [].Human MIC27 (also known as apolipoprotein O-like, APOOL) is also a subunit of the MICOS complex. It interacts with MIC26 and is involved in the formation of crista junctions [].
Short Name	MIC26/MIC27_animal