Protein Domain : Cytoplasmic polyadenylation element-binding protein IPR034819

Type	Family
Description	CPEB family members are RNA-binding proteins that are essential regulators of post-transcriptional gene expression. CPEBs target mRNAs defined by a cis-acting sequence in their 3' untranslated region (UTR), known as cytoplasmic polyadenylation element (CPE; with a consensus sequence of UUUUUAU). They are indirectly responsible for both translational repression and translational activation by polyadenylation [ ]. They are involved in may biological processes such as cell proliferation, senescence, cell polarity, and synaptic plasticity []. They regulate the translation of maternal mRNAs controlling meiotic cell cycle progression. Mammals have four CPEBs, CPEB1-4, among which CPEB1/2/4 are essential to successful mitotic cell division []. All four paralogues have two RNA recognition motifs (RRMs) and a zinc-binding domain (ZZ domain).Drosophila CPEB homologue is known as Orb2, which may have a role in long-term memory formation [ ].
Short Name	CPEB