Protein Domain : Poxvirus, Protein B14/B22/C16 IPR011212

Type  Family
Description  This is a family of conserved poxvirus proteins related to Protein B14 and Protein B22/C16 from Vaccinia virus. B14 contributes to virulence by binding to the host IKBKB subunit of the IKK complex and preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B. Mechanistically, it sterically hinders the direct contact between the kinase domains of IKBKB in the IKK complex containing IKBKB, CHUK/IKKA and NEMO [, , ].
Short Name  Poxvirus_B14/B22/C16

0 Child Features

0 Gene Families

0 Genes

0 Ontology Annotations

1 Parent Features

0 Publications

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