Protein Domain : Atypical protein kinase C, catalytic domain IPR034659

Type	Domain
Description	PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their N-terminal regulatory domain [ , ]. Atypical protein kinases C (aPKCs) have a PB1 and an atypical C1 domain, which only accepts phosphatidylserine [].In mammals there are two aPKC isoforms, zeta and iota/lambda (iota is the human orthologue and lambda the mouse orthologue) [ ]. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation [, ]. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes [, ].This entry consists mainly of invertebrate aPKCs. In Drosophila, aPKC is also involved in polarity maintenance, cytoskeletal regulation and cell cycle progression, and proliferation [, , , , ].
Short Name	Atypical_PKC