Protein Domain : XPA, conserved site IPR022658

Type	Conserved_site
Description	Xeroderma pigmentosum (XP) [ ] is a human autosomal recessive disease,characterised by a high incidence of sunlight-induced skin cancer. Skin cells of individual's with this condition are hypersensitive to ultraviolet light, due to defects in the incision step of DNA excision repair. There are a minimum ofseven genetic complementation groups involved in this pathway: XP-A to XP-G. XP-A is the most severe form of the disease and is due to defects in a 30kDanuclear protein called XPA (or XPAC) [ ].The sequence of the XPA protein is conserved from higher eukaryotes [ ] toyeast (gene RAD14) [ ]. XPA is a hydrophilic protein of 247 to 296 amino-acidresidues which has a C4-type zinc finger motif in its central section. This entry corresponds to the second conserved site in the XPA protein. It is a highly conserved region located some 12 residues after the zinc finger region
Short Name	XPA_CS