Protein Domain : MRPS27/PTCD2 IPR034913

Type  Family
Description  Mammalian pentatricopeptide repeat domain (PPR) proteins are involved in regulation of mitochondrial RNA metabolism and translation and are required for mitochondrial function. The supernumerary mitochondrial ribosomal protein of the small subunit 27 (MRPS27) is not required for mitochondrial RNA processing or the stability of the small ribosomal subunit. However, MRPS27 is required for mitochondrial protein synthesis [ ].Pentatricopeptide repeat-containing protein 2 (PTCD2) is a related mitochondrial PPR protein, although despite their similarity, they may not have the same function [ , ]. PTCD2 has a role in mitochondrial RNA metabolism and downstream effects on mitochondrial translation [, ]. PTCD2 has been identified as a target for autoantibodies in neurodegenerative disease and is used as a biomarker for Alzheimer disease [].
Short Name  MRPS27/PTCD2

2 Child Features

0 Gene Families

0 Genes

0 Ontology Annotations

0 Parent Features

0 Publications

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