Protein Domain : Retinoic acid receptor responder protein 1 IPR027261

Type  Family
Description  Retinoic acid receptor responder protein 1 (RARRES1) is also known as TIG-1 (tazarotene-induced gene-1) as it is up-regulated by the synthetic retinoid tazarotene [ , , ]. TIG-1 is a tumor suppressor gene, its expression being frequently downregulated through promoter hypermethylation in various carcinomas [, ]. Inhibits the cytoplasmic carboxypeptidase AGBL2, and may regulate the alpha-tubulin tyrosination cycle [].
Short Name  TIG1

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