v5.1.0.3
Cicer data from the Legume Information System
| Type | Family |
| Description | This entry includes APC membrane recruitment protein 1/2/3 (Amer1/2/3). Amer1, also known as WTX, binds to the tumour suppressor adenomatous polyposis coli and acts as an inhibitor of Wnt signaling by inducing beta-catenin degradation [ ]. Amer2 is a negative regulator of Wnt/beta-catenin signaling involved in neuroectodermal patterning [].WTX is a novel gene mutated in a proportion of Wilms' tumors and in patients suffering from sclerosing bone dysplasia []. |
| Short Name | AMER |