Protein Domain : Accessory protein NS7a, deltacoronavirus, HKU30-like IPR044332

Type	Domain
Description	This entry includes the accessory protein NS7a from Quail deltacoronavirus (QdCoV) UAE-HKU30 and sparrow deltacoronavirus (SpCoV-HKU17) within the Buldecovirus subgenus of deltacoronaviruses. In deltaCoVs, several avian species encode accessory protein NS7a, which is homologous to Porcine coronavirus (PDCoV) HKU15 accessory proteins NS7 and NS7a. PDCoV NS7a is a 100 amino-acid polypeptide identical to the C-terminal of NS7; it remains unclear whether their functions are redundant. The PDCoV NS7 protein is extensively distributed in the mitochondria and may be involved in various cellular processes such as cytoskeleton networks and cell communication, metabolism, and protein biosynthesis. NS7a proteins in this subfamily have yet to be characterised. Phylogenetic analysis revealed that QdCoV UAE-HKU30 belongs to the same CoV species as porcine deltacoronavirus (PdCoV) HKU15 and sparrow deltacoronavirus (SpdCoV) HKU17 within Buldecovirus subgenus, suggesting transmission between avian and swine hosts [ , , , ].
Short Name	NS7a_deltaCoV_HKU30-like