Protein Domain : FHF complex subunit HOOK interacting protein IPR019384

Type  Family
Description  This entry represents FHF complex subunit HOOK interacting proteins (FHIP, also known as FAM160) found in metazoa and fungi, which are components of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell [ ]. FHIP2A (FAM160B1) is required for proper functioning of the nervous system []. FHIP2B, previously described as retinoic acid-induced protein 16, is able to activate MAPK/ERK and TGFB signalling pathways and may play a role in cell proliferation [].
Short Name  FHIP

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