Protein Domain : Globin-sensor domain IPR044398

Type	Domain
Description	This domain is found at the N-terminal of globin-containing proteins mainly from bacteria, archaea and fungi [ ]. It is found in protoglobin, a single-domain globin of yet unknown biological function [], which has specific loops and an amino-terminal extension which leads to the burying of the heme within the matrix of the protein. Protoglobin-specific apolar tunnels allow the access of O2, CO and NO to the haem distal site [, ]. This domain can also recognise cyanide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).Proteins containing this domain include protoglobins from the strictly anaerobic methanogen Methanosarcina acetivorans and from the obligate aerobic hyperthermophile Aeropyrum pernix [ ]. This domain is also found in the N-terminal regions of HemAT from the archaeon Halobacterium salinarum (HemAT-Hs) and from the Gram-positive bacterium Bacillus subtilis (HemAT-Bs) []. It contains a myoglobin-like motif, displays characteristic heme-protein absorption spectra, and binds oxygen reversibly []. This domain is present in Diguanylate cyclase DosC (also known as YddV) from E. coli which is coupled with a C-terminal diguanylate cyclase (DGC/GGDEF) domain, which likely functions as a c-di-GMP cyclase in the synthesis of the second messenger cyclic-di-GMP (c-di-GMP) [].
Short Name	Globin-sensor_dom