Protein Domain : Nonstructural protein 2, HCoV-229E-like IPR044385

Type	Domain
Description	This entry represents NSP2 from alphacoronavirus, including human coronavirus 229E (HCoV-229E), Porcine epidemic diarrhea virus and related viruses [ ].The functions of NSP2 remain unclear. SARS-CoV NSP2, rather than playing a role in viral replication, may be involved in altering the host cell environment; deletion of NSP2 from the SARS-CoV genome results in only a modest reduction in viral titers, and it has been shown to interact with two host proteins, prohibitin 1 (PHB1) and PHB2 which have been implicated in cellular functions, including cell-cycle progression, cell migration, cellular differentiation, apoptosis, and mitochondrial biogenesis [ , ]. MHV NSP2, also known as p65, different from SARS-CoV NSP2, may play an important role in the viral life cycle [].
Short Name	NSP2_HCoV-229E-like