Protein Domain : Type IV pilus inner membrane component PilO IPR007445

Type	Family
Description	Bacterial type IV pili are surface filaments critical for diverse biological processes including surface and host cell adhesion, colonisation, biofilm formation, twitching motility, DNA uptake during natural transformation and virulence [ , ]. The proteins necessary to form the type IV pili inner-membrane complex, are included in the pilMNOPQ operon which encodes the cytoplasmic actin-like protein PilM, PilN, PilO, the periplasmic lipoprotein PilP and the outer-membrane secretin PilQ. The inner-membrane PilM/N/O/P complex is required for the optimal function of the outer-membrane secretin PilQ. This cluster is highly conserved across the type IV pilus-producing bacterial species, and all of these proteins have been shown to be essential for twitching motility [, ].This entry represents type IV pilus inner membrane component PilO, which is necessary for proper folding of PilN. PilO and PilN depend on each other for stability and the periplasmic domains of them interact to form a stable heterodimer, which is essential for the assembly of a functional complex [ , ].
Short Name	PilO