Protein Domain : Peroxidasin, peroxidase domain IPR034824

Type	Domain
Description	Peroxidasin is a secreted heme peroxidase which is involved in hydrogen peroxide metabolism and peroxidative reactions in the cardiovascular system [ , ]. It is a multidomain peroxidase that contain a signal peptide, several (e.g., five in Drosophila or one in Homo sapiens) leucine-rich regions, followed by four immunoglobulin-like domains, a linking region, the peroxidase domain, and a carboxy terminal Willebrand type C protein-protein interaction domain [, , ].This entry represents the peroxidase domain of peroxidasin and related proteins. The domain co-occurs with extracellular matrix domains and may play a role in the formation of the extracellular matrix [ ].This entry also includes the human peroxidasin-like protein (PDXNL), a probable oxidoreductase that lacks peroxidase activity. It inhibits the peroxidase activity of PXDN through its interaction [ ].
Short Name	Peroxidasin_peroxidase