Protein Domain : Nitrobindin family IPR045165

Type	Family
Description	Nitrobindins (Nbs) are evolutionary conserved all-β-barrel heme-proteins displaying a highly solvent-exposed heme-Fe(III) atom. Mycobacterium tuberculosis Nb (Mt-Nb(III) and the C terminus of Homo sapiens Nb (Hs-Nb(III)) share this β-barrel structure, suggesting that Nb may act as a sensor possibly modulating the THAP4 transcriptional activity residing in the N-terminal region [ ]. Ferric nitrobindin-like proteins that lack the conserved His residue which binds heme iron are also included in the Nb family.Mt-Nb(III) is a peroxynitrite isomerase that converts peroxynitrite to nitrate. It may be required to scavenge reactive nitrogen and oxygen species produced by the host during the immunity response [ ]. In humans THAP4 catalyses the heme-based conversion of peroxynitrite into nitrate/NO3 in vitro [ ]. At1g79260 is a nitrophorin-like heme-binding protein that may reversibly bind nitric oxide (NO) and be involved in NO transport []. This entry also includes Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology [].
Short Name	Nitrobindin