Protein Domain : Gasdermin IPR007677

Type	Family
Description	The precise function of this protein is unknown. However, it is thought that this entry represents the gasdermin family which plays a role as a secretory or metabolic product involved in the secretory pathway and includes gasdermins A-E (GSDMA-E). A N-terminal fragment released by proteolysis of gasmerdin A binds to lipids and homo-oligomerizes in the membrane forming pores, which may have a bactericidal function [ ].GSDMB (GSDM) may play a role in achieving and maintaining the final differentiation state of epithelial cells [ , ]. A deletion/insertion mutation in GSDMB (DFNA5) is associated with an autosomal dominant non-syndromic hearing impairment form [].Certain gasdermins are cleaved by inflammatory and apoptotic caspases [ ]. Gasmedin E is cleaved by caspase-3 and the N-terminal fragment released forms pores in the cell membrane, switching from cell death by apoptosis to pyroptosis [].
Short Name	Gasdermin