Protein Domain : Sorting nexin-9, BAR domain IPR037425

Type	Domain
Description	Sorting nexin 9 (SNX9) has been suggested to be involved in the endocytic process as an accessory factor [ ]. SNX9 has binding sites for both clathrin and adaptor protein AP-2 in a low complexity region, and binds dynamin-2 (Dyn2) by its SH3 domain. SNX9 has its own membrane-binding activity, mediated by a carboxyl-terminal region containing the PX domain and the BAR domain []. Endogenous SNX9 partially co-localizes with AP-2 and Dyn2 at the plasma membrane, and over expression in K562 and HeLa cells of truncated versions of SNX9 inhibits the uptake of transferrin []. Moreover, SNX9 is required for efficient clathrin-mediated endocytosis, which suggests that it functions to regulate dynamin activity [].SNXs are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNX9 also contains a BAR and a SH3 domain. This entry represents the BAR domain of sorting nexin-9. BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions [ ].
Short Name	SNX9_BAR