Protein Domain : Harmonin-binding protein USHBP1, PDZ-binding domain IPR019536

Type	Domain
Description	The entry represents the PDZ-binding domain of Harmonin-binding protein USHBP1 (also known as MCC2, mutated in colon cancer-2). USHBP1 has high homology to tumour suppressor MCC1 (mutated in colon cancer-1).MCC2 protein binds the first PDZ domain of AIE-75 (also known as Harmonin) with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumour suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75 [ , ].
Short Name	USHBP1_PDZ-bd