Protein Domain : Wee1-like protein kinase IPR017164

Type	Family
Description	This group represents a Wee1-like protein kinase ( ), which is a key regulator for G(2)-to-M progression. This enzyme phosphorylates Tyr15 on Cdc2 (cell division control protein 2) when Cdc2 is complexed to cyclin B1, which results in blocking the progression of cells into M phase [ ]. As such, it negatively regulates the entry of a cell into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed Cdc2 before the onset of mitosis [, ]. The activity of this enzyme increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated; it is then ubiquitinated and degraded at the onset of G2/M phase.
Short Name	Wee1-like_protein_kinase