Protein Domain : Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2, I-BAR domain IPR030126

Type	Domain
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 (Baiap2l2), also known as planar intestinal and kidney specific BAR domain protein (Pinkbar), is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [ ].In humans Baiap2l2 is specifically expressed in intestinal epithelial cells, where it localises to Rab13-positive vesicles and to the plasma membrane at intercellular junctions [ ]. The BAR domain of Baiap2l2 does not induce membrane protrusions or invaginations; instead, it promotes the formation of planar membrane sheets []. This entry represents the N-terminal I-BAR domain, also known as IRSp53/MIM homology Domain (IMD), of Baiap2l2.
Short Name	Baiap2l2_I-BAR_dom

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