Protein Domain : Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain IPR029190

Type  Domain
Description  This entry represents the C-terminal domain of the ribosomal RNA-processing protein 14 (Rrp14), which shares protein sequence similarity with surfeit locus protein 6 (SURF6). In mammals, SURF6 is a component of the nucleolar matrix and has a strong binding capacity for nucleic acids [ ]. SURF6 is always found in the nucleolus regardless of the phase of the cell cycle suggesting that it is a structural protein constitutively present in nucleolar substructures. A role in rRNA processing has been proposed for this protein. Saccharomyces cerevisiae member of the SURF-6 family, named Rrp14 (ribosomal RNA-processing protein 14), interacts with proteins involved in ribosomal biogenesis and cell polarity [ ]. It is required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis [, ].
Short Name  Rrp14/SURF6_C

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