Protein Domain : Penicillin-binding protein Tp47 domain A IPR029221

Type	Domain
Description	This is the first domain in Tp47, an unusual penicillin-binding protein (PBP) from Treponema pallidum. It is mainly composed of β-strands and is sequentially non-contiguous. The first three domains in Tp47 interact with each other through intimate domain-domain interfaces. Domain A contacts domain B through its N-terminal segment. Domain A also interacts tightly with domain C. Tp47 is unusual in that it displays beta-lactamase activity, and thus it does not fit the classical structural and mechanistic paradigms for PBPs. Tp47 appears to represent a new class of PBP [ ].
Short Name	PBP-Tp47_A