Protein Domain : Transcription regulator HTH, HdfR IPR020890

Type	Family
Description	Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including AmpR, CatM, CatR, CynR, CysB, GltC, IlvY, IrgB, LysR, MetR, NhaR, SyrM, TcbR, TfdS and TrpI [ , , , , ]. The majority of these proteins appear to be transcription activatorsand most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-terminal end.The hdfR gene encodes a LysR family protein. HdfR is able to bind to the flhDC promoter, indicating that HdfR is a transcriptional regulator for the flagellar master operon. Furthermore, the expression of the hdfR gene was shown to be negatively regulated by H-NS [ ].
Short Name	Tscrpt_reg_HTH_HdfR