Protein Domain : Penicillin-binding protein Tp47, domain C IPR029218

Type	Domain
Description	Domain C is the largest domain in this unusual penicillin-binding protein (PBP), Tp47. This domain is mainly characterised by an immunoglobulin fold with two opposing β-sheets that form the typical barrel-like structure. In contrast to the classical immunoglobulin fold, however, this has an additional β-strand inserted after strand 3. Also, the strands are connected by rather large loops. Helices are inserted between strands 2 and 3 and between strands 4 and 5. Domain C interacts with domain B via a surface that has a slightly concave, goblet-like shape in addition to interacting tightly with domain A and weakly with domain D. Tp47 is unusual in that it displays beta-lactamase activity, so it does not fit the classical structural and mechanistic paradigms for PBPs, and thus Tp47 appears to represent a new class of PBP [ ].
Short Name	PBP-Tp47_dom_C