Protein Domain : Transcription factor ATOH7, basic helix-loop-helix IPR032663

Type	Domain
Description	The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two α-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [ ].Transcription factor ATOH7 (previously known as Protein atonal homologue 7, Atoh7, and Math5) is a basic helix-loop-helix transcription factor that is involved in early stages of retinal neurogenesis [ , , ]. It is specifically expressed in the embryonic neural retina and is required for the genesis of retinal ganglion cells (RGCs) and optic nerves [ ].This entry represents the bHLH domain of ATOH7 and similar proteins from chordates.
Short Name	ATOH7_bHLH