Protein Domain : Inosine triphosphate pyrophosphatase-like IPR029001

Type	Homologous_superfamily
Description	This entry represents the inosine triphosphate pyrophosphatase (ITPase)-like proteins. Members in this family include NTPases, such as Ham1-like protein (non-canonical purine NTP pyrophosphatase) and non-canonical purine NTP phosphatase (YjjX-like), Maf-like proteins and PRRC1.Non-canonical purine NTP phosphatases are prokaryotic phosphatases that hydrolyse non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives [ ].Ham1 is a pyrophosphatase that hydrolyses the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives [ ].Maf proteins exhibit nucleotide pyrophosphatase activity against canonical and modified nucleotides [ ]. Proline-rich and coiled-coil-containing protein 1 (PRRC1) is a Golgi-associated protein of unknown function [].
Short Name	ITPase-like_fam