LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | AT-rich interactive domain-containing protein 1A (ARID1A or BAF250a) is part of the SWI/SNF-like ATP-dependent chromatin remodelling complex that regulates gene expression through regulating nucleosome remodelling [ , ]. In humans there are two BAF250 isoforms, BAF250a/ARID1A and BAF250b/ARID1B []. Both BAF250a and BAF250b bind DNA non-specifically []. They are thought to be E3 ubiquitin ligases that target histone H2B []. BAF250a plays key roles in maintaining embryonic stem cell pluripotency and in cardiac development and function [, ]. The BAF250a gene is a tumour suppressor gene that is frequently mutated in ovarian clear cell carcinoma [].This entry represents the ARID/BRIGHT DNA binding domain of ARI1A. It binds DNA in a non-sequence-specific manner similar to ARID1B [ ]. |
| Short Name | ARID1A_ARID_BRIGHT_DNA-bd |
