Protein Domain : Cilium assembly protein DZIP1, N-terminal IPR032714

Type	Domain
Description	This entry represents the N-terminal region of the cilium assembly protein DZIP1, which acts as a molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body [ , , , ]. It also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium []. DZIP1 is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum [] and it is also indirectly involved in heart development through its function in ciliogenesis []. Zebrafish Dzip1 acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals []. It is required for establishment of left-right asymmetry during embryogenesis and has a role in primary cilium formation [].
Short Name	DZIP1_N