Protein Domain : Agouti IPR007733

Type  Family
Description  The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP) is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation [ , ]. This family also includes the Agouti-related protein (Agrp), involved in energy balance, body weight regulation and metabolism. It interacts with melanocortin receptors MC3R, MC4R and MC5R [].This family also includes Toxin Tbo-IT2 from Oblong running crab spider, which contains an inhibitor cystine knot (ICK) fold with a spatial structure and very similar Cys distribution to agouti-signaling proteins (ASIP) and agouti-related proteins (AGRP) [ ].
Short Name  Agouti

0 Child Features

0 Gene Families

0 Genes

2 Ontology Annotations

0 Parent Features

0 Publications

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