LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | DCAFs, Ddb1- and Cul4-associated factors, are substrate receptors for the Cul4-Ddb1 Ubiquitin Ligase. There are 18 different factors, the majority of which are WD40-repeat-proteins [ ]. DDB1- and CUL4-associated factor 15 (DCAF15) is the substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins [], and acts as a regulator of the natural killer (NK) cells effector functions []. Aryl sulfonamide anticancer agents appear to promote binding of DCAF15 to the RNA-recognition motif (RRM) of RBM39, which suggests that derivatives of the aryl-sulfonamides may be used to target other RRM-containing proteins [, ].This entry represents the WD40 repeat-containing N-terminal domain found in DCAF15 and similar animal proteins. |
| Short Name | DCAF15_WD40 |
