Protein Domain : RNA methyltransferase TrmA, conserved site IPR030391

Type	Conserved_site
Description	In Escherichia coli, the trmA protein is a tRNA (uracil-5-)-methyltransferase () that catalyses the S-adenosylmethionine dependent methylation of U54 in all tRNAs. Orthologues of trmA are found in many eubacterial species. A number of uncharacterised homologues of trmA have been found [ ]:Escherichia coli hypothetical protein ygcA and HI0333, the corresponding Haemophilus influenzae protein.Haemophilus influenzae hypothetical protein HI0958.Chlamydia trachomatis protein HOM1.Fission yeast hypothetical protein SpAC4G8.07c.It is probable that ygcA/HI0333 and HI0958 are responsible for the methylation of U747 and U1939 in 23S rRNA. In trmA, a cysteine is known toparticipate in the catalytic mechanism by forming a covalent adduct to C6 of uracil.This entry represents a conserved site located at the C-terminal end. It contains a conserved histidine.
Short Name	MeTrfase_TrmA_CS