Protein Domain : Ankycorbin/UACA IPR042420

Type	Family
Description	This family includes a group of membrane-shaping proteins that can promote local membrane curvatures, termed N-Ank proteins, which use their ankyrin repeat array and an N-terminal amphipathic helix to bind and shape membranes. The N-Ank superfamily can be divided in two subfamilies, the smaller one contains ankycorbin (also known as RAI14), UACA, Ankyrin repeat domain-containing protein 24 and 35 (Ankrd24/35); the larger second subfamily includes the uncharacterised proteins of the Ankrd18, Ankrd30 and Ankrd20 subfamilies, which all are specific to primates, or even to humans, as well as Ankrd7, Ankrd26, Ankrd36 and Ankrd62 [ ].This entry represents the smaller N-Ank subfamily. Ankycorbin is an actin binding protein that regulates F-actin dynamics [ , ]. It plays an important role in early morphogenesis of neurons which depends on ankyrin repeat and N-terminal amphipathic helix. UACA (also known as Nucling) mediates apoptosis, regulates NF-κB and STAT3, sequesters par-4 and acts as an autoantigen in patients with panuveitis [, ]. Ankrd24/35 are uncharacterised proteins. Ankrd35 is associated with chronic myeloid leukaemia [].
Short Name	RAI14/UACA