Protein Domain : Histone H3-K79 methyltransferase IPR030445

Type	Family
Description	The enzymes that catalyse histone methylation are classified into 3 families: the PRMT (protein arginine N-methyltransferase) family, the SET-domain-containing family, and the non-SET domain proteins. Lysine 79 (K79) of H3 is methylated by a methyltransferase represented in this entry that lacks a SET domain [ ].H3K79 methylation occurs in a variety of organisms ranging from yeast to human. In budding yeast, K79 methylation is mediated by the silencing protein Dot1 [ ]. Dot1 homologues can be found in a variety of eukaryotic organisms; in mammals the homologous protein is called Dot1-like protein (DOT1L) [, ]. Dot1/DOT1L catalyses the sequential mono-, di-, and tri-methylation of H3K79, while SET domain-containing methyltransferases mediate methylation in a processive manner []. K79 methylation level is regulated throughout the cell cycle and plays a critical role in the progression of G1 phase, S phase, mitosis, and meiosis [].
Short Name	H3-K79_meTrfase