Protein Domain : Tax1-binding protein 3 IPR017268

Type	Family
Description	This entry represents Tax1-binding protein 3, also known as TIP-1, which is a PDZ domain-containing protein that functions in a wide variety of biological events through selective interaction with different proteins. It interacts with the RhoA effector protein rhotekin [ ]. It also associates with glutaminase L [], potassium channel Kir2.3 [] and NMDA receptors []. In humans, Tax1-binding protein 3 has been shown to be involved in the activation of Cdc42 by the viral protein HPV16 E6 []. TIP-1 can have both an oncogenic function or act as a tumor suppressor, probably by modulating the transcriptional activity of beta-catenin [, ].
Short Name	Tax1-binding_p3